Severe traumatic bleeding remains one of the most preventable causes of death worldwide, highlighting the urgent need for integrated advances in science, clinical practice, and regulation. This international Symposium brings together leaders in trauma medicine, transfusion science, military medicine, and regulatory policy to define the current state of the science in resuscitation medicine and to outline a shared European vision for the future of trauma care. The programme spans the full spectrum of research and practice from the underlying biology of trauma-induced coagulopathy and haemorrhagic shock to next-generation assays, therapeutics, and haemostatic resuscitation strategies. Sessions will also address prehospital blood programmes, training requirements, implementation challenges, and the specific needs of vulnerable and special populations, integrating lessons from both civilian and military contexts. A strong emphasis is placed on European collaboration and regulatory harmonization, with discussion of the new European Regulation on Substances of Human Origin (SoHO) and the vital roles of patients and voluntary donor associations in addition to NATO Forces medical preparation for large scale combat operations. By connecting mechanistic insights, clinical evidence, and policy frameworks, the conference aims to accelerate innovation, strengthen system readiness, and ensure that advances in resuscitation medicine translate into improved survival and equitable access to care across Europe and beyond.
Resuscitation medicine and haemostatic strategies
Evidence-based approaches to haemostatic resuscitation, including the role of plasma, antifibrinolytics, calcium, platelets, fibrinogen, PCCs, and evolving transfusion paradigms across prehospital and in-hospital settings.
Trauma-induced coagulopathy and haemorrhagic shock biology
Mechanistic insights into endotheliopathy of trauma, platelet dysfunction, fibrinolysis, thromboinflammation, and the biological signatures of haemorrhagic shock. Focus on endotyping and precision-oriented frameworks to guide decision-making and improve outcomes.
Innovation: next-generation assays and therapeutics
Emerging diagnostic platforms, multi-omics approaches, and technology-enabled treatment algorithms, including the role of artificial intelligence in decision support. Discussion of translational pathways and what is required for scalable adoption.
Regulatory and system readiness: SoHO and European harmonization
Regulatory perspectives under the new European Regulation on Substances of Human Origin (SoHO), with attention to harmonization, surge capacity, quality assurance, and alignment of safety, innovation, and public trust across European health systems.
LSCO preparedness and military-civilian interoperability
Clinical and logistical readiness for large-scale combat operations (LSCO), including expected casualty patterns, transport constraints, supply chain resilience, and operational planning. Interfaces between NATO objectives and European systems for trauma and transfusion preparedness.
This meeting is designed for a focused audience of experts and stakeholders involved in resuscitation science and its implementation, including: